MovDisordV3, Main, Exploration, bibRecord, 001953

The pharmacological treatment for uremic restless legs syndrome: Evidence‐based review

Identifieur interne : 001953 ( Main/Exploration ); précédent : 001952; suivant : 001954

The pharmacological treatment for uremic restless legs syndrome: Evidence‐based review

Auteurs : Márcio Moysés De Oliveira [Brésil] ; Cristiane Fiquene Conti [Brésil] ; Juliana Spelta Valbuza [Brésil] ; Luciane Bizari Coin De Carvalho [Brésil] ; Gilmar Fernandes Do Prado [Brésil]

Source :

Movement Disorders [ 0885-3185 ] ; 2010-07-30.

RBID : ISTEX:04824B1548A65B83C660098381805668157E900D

English descriptors

KwdEn :
- Cross-Over Studies, Databases, Factual (statistics & numerical data), Double-Blind Method, Evidence-Based Medicine, Humans, Randomized Controlled Trials as Topic, Restless Legs Syndrome (complications), Restless Legs Syndrome (drug therapy), Uremia (drug therapy), Uremia (etiology), end‐stage renal disease, restless legs syndrome, systematic review, uremic.
MESH :
- complications : Restless Legs Syndrome.
- drug therapy : Restless Legs Syndrome, Uremia.
- etiology : Uremia.
- statistics & numerical data : Databases, Factual.
- Cross-Over Studies, Double-Blind Method, Evidence-Based Medicine, Humans, Randomized Controlled Trials as Topic.

Abstract

Restless legs syndrome (RLS) is a common and often misdiagnosed entity among the general population and it may be more common among dialysis patients, with an estimated prevalence of 6.6 to 21.5%. The treatment for uremic RLS has been controversial and therefore a systematic synthesis of the evidence is needed in order to evaluate the effectiveness and safety of treatments for uremic RLS. This was a systematic review of randomized or quasi‐randomized double‐blind trials on treatments for uremic RLS. The outcomes considered were relief of RLS symptoms marked on a validated scale, subjective sleep quality, sleep quality measured using night polysomnography and actigraphy, quality of life measured subjectively, and adverse events associated with these treatments. Six eligible clinical trials were included. The results from subjective analyses in these studies were divergent, although objective analyses in one trial showed that there was a statistically significant improvement in periodic leg movement while asleep in the treatment group. No combined analysis (meta‐analysis) was performed. The most common adverse event seen was gastrointestinal symptoms. Only a few therapeutic trials on patients with uremia with RLS have been published, and there is insufficient scientific evidence to favor any specific therapeutic regimen for uremic‐associated RLS. Therapy using levodopa, dopaminergic agonists, anticonvulsants, and clonidine tend to be effective, but further studies are needed. © 2010 Movement Disorder Society

Url:

https://api.istex.fr/document/04824B1548A65B83C660098381805668157E900D/fulltext/pdf

DOI: 10.1002/mds.22955

Affiliations:

Le document en format XML

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<front><div type="abstract" xml:lang="en">Restless legs syndrome (RLS) is a common and often misdiagnosed entity among the general population and it may be more common among dialysis patients, with an estimated prevalence of 6.6 to 21.5%. The treatment for uremic RLS has been controversial and therefore a systematic synthesis of the evidence is needed in order to evaluate the effectiveness and safety of treatments for uremic RLS. This was a systematic review of randomized or quasi‐randomized double‐blind trials on treatments for uremic RLS. The outcomes considered were relief of RLS symptoms marked on a validated scale, subjective sleep quality, sleep quality measured using night polysomnography and actigraphy, quality of life measured subjectively, and adverse events associated with these treatments. Six eligible clinical trials were included. The results from subjective analyses in these studies were divergent, although objective analyses in one trial showed that there was a statistically significant improvement in periodic leg movement while asleep in the treatment group. No combined analysis (meta‐analysis) was performed. The most common adverse event seen was gastrointestinal symptoms. Only a few therapeutic trials on patients with uremia with RLS have been published, and there is insufficient scientific evidence to favor any specific therapeutic regimen for uremic‐associated RLS. Therapy using levodopa, dopaminergic agonists, anticonvulsants, and clonidine tend to be effective, but further studies are needed. © 2010 Movement Disorder Society</div>
</front>
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Movement Disorders (revue)

The pharmacological treatment for uremic restless legs syndrome: Evidence‐based review

The pharmacological treatment for uremic restless legs syndrome: Evidence‐based review

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
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